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Pono nā ʻepekema biomedical e hana hou aʻe e hoʻomaikaʻi i ka pili a me ka reproducibility o ka noiʻi moʻomeheu cell

Hoʻohana mākou i nā kuki e hoʻonui i kou ʻike.Ma ka hoʻomau ʻana i ka nānā ʻana i kēia pūnaewele, ʻae ʻoe i kā mākou hoʻohana ʻana i nā kuki.ʻIke hou aku.
Pono e hoʻomaʻamaʻa ʻia nā hōʻike noiʻi biomedical o nā pūnana mammalian i ʻoi aku ka maʻamau a me ka kikoʻī, a i ʻoi aku ka maikaʻi o ka mālama ʻana a me ke ana ʻana i nā kūlana kaiapuni o ka moʻomeheu cell.ʻO kēia ka mea e ʻoi aku ka pololei o ka hoʻohālikelike ʻana i ka physiology kanaka a kōkua i ka reproducibility o ka noiʻi.
Ua kālailai kekahi hui o KAUST ʻepekema a me nā hoa hana ma Saudi Arabia a me ʻAmelika Hui Pū ʻIa i 810 mau pepa i wae ʻia ma nā laina kelepona mammalian.ʻOi aku ka liʻiliʻi ma mua o 700 o lākou i komo i ka 1,749 mau hoʻokolohua moʻomeheu kelepona hoʻokahi, me ka ʻikepili kūpono e pili ana i nā kūlana kaiapuni o ka moʻomeheu cell.Hōʻike ka hōʻike ʻana o ka hui he nui nā hana e pono ai e hoʻomaikaʻi i ka pili a me ka hana hou ʻana o ia mau haʻawina.
E hoʻoulu i nā pūnaewele i loko o kahi incubator i hoʻomaluʻia e like me nā protocols maʻamau.Akā, e ulu ana nā pūnaewele a "hanu" i ka manawa, e hoʻololi i ke kinoea me ke kaiapuni a puni.E pili ana kēia i ka nohona kūloko kahi e ulu ai lākou, a hiki ke hoʻololi i ka ʻakika o ka moʻomeheu, oxygen dissolved, a me nā ʻāpana kalapona kalapona.Hoʻololi kēia mau hoʻololi i ka hana cell a hiki ke hoʻokaʻawale i ke kūlana kino mai ke ʻano o ke kino kanaka ola.
"ʻO kā mākou noiʻi e hoʻokūpaʻa i ka nui o ka poʻe ʻepekema i mālama ʻole i ka nānā ʻana a me ka mālama ʻana i ke kaiapuni kelepona, a i ka nui o nā hōʻike e hiki ai iā lākou ke hōʻea i nā hopena ʻepekema ma nā ʻano kikoʻī," wahi a Klein.
No ka laʻana, ua ʻike nā mea noiʻi ma kahi o ka hapalua o nā pepa analytical ʻaʻole i hōʻike i ka mahana a me nā hoʻonohonoho kalapona kalapona o kā lākou moʻomeheu cell.Ma lalo o 10% i hōʻike i ka maʻiʻo oxygen o ka lewa i loko o ka incubator, a ma lalo o 0.01% i hōʻike i ka acidity o ka medium.ʻAʻohe pepa i hōʻike ʻia e pili ana i ka oxygen dissolved a i ʻole carbon dioxide ma ka pāpā.
Pīhoihoi loa mākou i ka nānā ʻole ʻana o nā mea noiʻi i nā kumu kūlohelohe e mālama i nā pae pili physiologically i ka wā o ke kaʻina holoʻokoʻa o ka moʻomeheu cell, e like me ka moʻomeheu acidity, ʻoiai ua ʻike ʻia he mea nui kēia no ka hana cell.”
Ke alakaʻi ʻia nei ka hui e Carlos Duarte, he kanaka ʻepekema kai ma KAUST, a ʻo Mo Li, he mea ola ola kino, me ka hui pū ʻana me Juan Carlos Izpisua Belmonte, he mea hoʻomohala hoʻomohala ma ka Salk Institute.He kaukaʻi kipa ʻo ia i kēia manawa ma KAUST a paipai i nā ʻepekema biomedical e hoʻomohala i nā hōʻike maʻamau A me nā kaʻina hana hoʻomalu a me ke ana ʻana, ma waho aʻe o ka hoʻohana ʻana i nā mea hana kūikawā no ka mālama ʻana i ka nohona moʻomeheu o nā ʻano cell like ʻole.Pono nā puke pai ʻepekema e hoʻokumu i nā kūlana hōʻike a koi aku i ka nānā pono ʻana a me ka mālama ʻana i ka acidity media, oxygen dissolved a me carbon dioxide.
"ʻOi aku ka maikaʻi o ka hōʻike ʻana, ana, a me ka hoʻomalu ʻana i nā kūlana kaiapuni o ka moʻomeheu cell e hoʻomaikaʻi i ka hiki o nā ʻepekema ke hana hou a hana hou i nā hopena hoʻokolohua," wahi a Alsolami."Hiki i ka nānā ʻana i nā mea hou a hoʻonui i ka pili o ka noiʻi preclinical i ke kino kanaka."
"ʻO ka moʻomeheu mammalian cell ke kumu no ka hana ʻana i nā lāʻau lapaʻau maʻi a me nā biotechnologies ʻē aʻe," wehewehe ʻo Shannon Klein ka mea ʻepekema moana."Ma mua o ka hoʻāʻo ʻana i nā holoholona a me nā kānaka, hoʻohana ʻia lākou e aʻo i ka biology cell basic, replicate mechanical mechanisms, and study the toxic of new drug compound."
Klein, SG, etc. (2021) Pono nā hana maikaʻi loa i ka mālama ʻole ʻana i ke kaiapuni i ka moʻomeheu cell mammalian.ʻEnekinia Biomedical Natural.doi.org/10.1038/s41551-021-00775-0.
Tags: B cell, cell, cell culture, incubator, mammalian cell, manufacturing, oxygen, pH, physiology, preclinical, noiʻi, T cell
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Ka manawa hoʻouna: Sep-07-2021