ʻO nā dipeptides

ʻAʻole i aʻo ʻia ʻo L-α-dipeptides (dipeptides) e like me ka nui o nā protein a me nā waikawa amino.Ua hana ʻia ka noiʻi mua ma L-aspartyl-L-phenylalanine methylester (aspartame) a me Ala-Gln (Lalanyl-L-glutamine) no ka mea ua hoʻohana ʻia lākou i nā huahana kālepa kaulana.Ma waho aʻe o kēia ʻoiaʻiʻo, ʻo kekahi kumu ʻaʻole i aʻo maikaʻi ʻia ka nui o nā dipeptides no ka mea ʻaʻole i nele ka hana ʻana o ka dipeptide i nā kaʻina hana pono, ʻoiai ua hōʻike ʻia kekahi mau hana kemika a me chemoenzymatic.

Carnosine - laʻana o ka dipeptide
A hiki i kēia manawa, ua hoʻomohala ʻia nā ʻano hou no ka synthesis dipeptide i hana ʻia nā dipeptides ma o nā kaʻina fermentative.Loaʻa i kekahi mau dipeptides nā mana physiological kūʻokoʻa, e ʻae iā lākou e wikiwiki i nā noi dipeptide ma nā ʻano ʻano noiʻi ʻepekema.Loaʻa nā L-α-dipeptides i ka paʻa peptide paʻakikī loa o nā waikawa amino ʻelua, akā ʻaʻole hiki ke loaʻa ma muli o ka nui o nā kaʻina hana kumu kūʻai.ʻO nā dipeptides naʻe, he mau hana hoihoi loa, a ke piʻi nei ka ʻike ʻepekema a puni lākou.Ke waiho nei kēia i nā mea noiʻi he nui ke kuleana o ka hoʻomohala ʻana i nā kaʻina hana ʻoi aku ka maikaʻi a me ke kumu kūʻai o ka hana dipeptide.Ke aʻo piha ʻia kēia kahua, ua manaʻo ʻia e hiki iā mākou ke aʻo hou aʻe e pili ana i ka waiwai maoli o nā peptides.

ʻElua mau hana maʻamau o Dipeptides, ʻo ia hoʻi:
1. He mea hoʻopuka o nā ʻakika amino
2. ʻO ka dipeptide pono'ī

Ma ke ʻano he derivative o nā amino acids, nā dipeptides, me kā lākou mau amino acids i loaʻa nā waiwai physiochemical like ʻole, akā maʻamau lākou e like me nā hopena physiological like.ʻO kēia no ka mea, ua hoʻohaʻahaʻa ʻia nā dipeptides i loko o nā ʻakika amino ʻokoʻa i loko o nā mea ola, nona nā waiwai physicochemical like ʻole.No ka laʻana, ʻo L-glutamine (Gln) ka wela-labile, aʻo ka Ala-Gin (L-alanyl-L-glutamine) he ʻae wela.

ʻO ka synthesis kemika o nā dipeptides e like me kēia:
1. Mālama ʻia nā pūʻulu dipeptide hana āpau (ma waho aʻe o nā mea i komo i ka hana ʻana i ka paʻa peptide o nā waikawa amino).
2. Ho'ā ka amino acid o ka hui carboxyl manuahi.
3. Hoʻopili ʻia ka ʻakika amino i hoʻōla ʻia me ka ʻakika amino pale ʻē aʻe.
4. Hoʻopau ʻia nā hui pale i loko o ka dipeptide.